Efficacy and safety of active ultrafine mesh stents

Project summary

CONTEXT

Over the past 20 years, major technological advances in the design and mechanical properties of stents have improved clinical outcomes in patients undergoing coronary angioplasty and active drug-eluting stents have become the gold standard. Although second-generation active stents are associated with excellent clinical performance leading to a marked reduction in late and very late stent thrombosis, long-term revascularization failures mainly related to in-stent restenosis are still observed. As a result, technical progress has led to the current 3rd and 4th generations of active stents. However, stents with biodegradable polymer or polymer-free drug-releasing stents, potentially linked to chronic vessel inflammation, have not demonstrated significant clinical benefit on ischemic parameters in recent trials.

GOALS

This study aims to evaluate the short- and long-term effectiveness and safety of ultrafine mesh active stents compared to contemporary second-generation active stents in the treatment of coronary artery disease.

METHODOLOGY

Descriptive analyzes and comparisons between 2 groups: ultrafine mesh stents (<70um and depending on stent diameters for each platform) and contemporary stents without ultrafine mesh (>70um)

- Subgroup analyzes